Under almost the same reaction conditions, carboxyl can act as either a classical directing group or a traceless directing group, thereby generating two kinds of products, i.e., 2‐alkyl

Weinreb amides are a privileged, multi-functional group with well-established utility in classical synthesis. Recently, several studies have demonstrated the use of Weinreb amides as interesting substrates in transition metal-catalyzed C-H functionalization reactions. Herein, we review this part of the literature, including the metal catalysts, transformations explored so far and specific Publication – Huang Group 15. Traceless Directing Strategy Efficient Synthesis of N-Alkyl Indoles via Redox-Neutral C–H Activation Chengming Wang and Yong Huang*, Org. Lett. 2013, 15, 5294-5297. A general protocol for the synthesis of N-alkyl indoles has been developed via a redox neutral C–H activation strategy using a traceless nitroso directing group. Stereodivergent synthesis of 1,4-dicarbonyls by traceless Aug 17, 2018 Marc Font - Postdoctoral Research Fellow - Universidad de obstacle consists of installing directing groups into substrates to direct the functionalisation towards the desired C–H bond, leaving behind the directing group in the molecule. Alternatively, carboxylic acids have been employed as traceless directing groups that are easily removed after carboxylic acid-directed

Molecules | Free Full-Text | Weinreb Amides as Directing

15. Traceless Directing Strategy Efficient Synthesis of N-Alkyl Indoles via Redox-Neutral C–H Activation Chengming Wang and Yong Huang*, Org. Lett. 2013, 15, 5294-5297. A general protocol for the synthesis of N-alkyl indoles has been developed via a redox neutral C–H activation strategy using a traceless nitroso directing group. Stereodivergent synthesis of 1,4-dicarbonyls by traceless Aug 17, 2018

Weinreb amides are a privileged, multi-functional group with well-established utility in classical synthesis. Recently, several studies have demonstrated the use of Weinreb amides as interesting substrates in transition metal-catalyzed C-H functionalization reactions. Herein, we review this part of the literature, including the metal catalysts, transformations explored so far and specific

molecules (Scheme 1). Traceless directing groups, the removal of which does not require additional steps, would be more attractive alternatives. However, the functional groups that can be employed as the traceless directing groups remain relatively rare.3 Recently, carboxylic acid,4 N-oxide,5 silicon-tethered,6 Dichloromethane as a methylene synthon for regioselective Jun 01, 2019